COX2 Recombinant Rabbit Monoclonal Antibody [6J8]
Catalog# RE6064
COX2 Recombinant Rabbit Monoclonal Antibody [6J8]
-
WB
-
IF-Cell
-
Human
-
Mouse
-
unconjugated
Overview
Product Name
COX2 Recombinant Rabbit Monoclonal Antibody [6J8]
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
peptide
Species Reactivity
Human, Mouse
Validated Applications
WB, IF-Cell
Molecular Weight
72kDa
Positive Control
Raw264.7
Conjugation
unconjugated
Clone Number
6J8
Product Features
Form
Liquid
Concentration
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
WB
-
1:1,000
-
IF-Cell
-
1:100
Target
Function
Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general "housekeeping" functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs.
Background References
1. Hsu CK et al. Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation. J Cell Physiol 230:702-15 (2015).
2. Zhao L et al. Effect of Chronic Psychological Stress on Liver Metastasis of Colon Cancer in Mice. PLoS One 10:e0139978 (2015).
Subcellular Location
Microsome membrane,Endoplasmic reticulum membrane
UNIPROT
Synonyms
COX 2 antibody
COX-2 antibody
COX2 antibody
Cyclooxygenase 2 antibody
Cyclooxygenase 2b antibody
Cyclooxygenase antibody
Cyclooxygenase-2 antibody
Cyclooxygenase2 antibody
EC 1.14.99.1 antibody
fj02a10 antibody
ExpandImages
-
Western blot analysis on Raw264.7 cell lysate + LPS using anti-COX2.
-
Immunocytochemical analysis of paraffin-embedded Raw264.7 cells using anti-COX2.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Citation
-
Ginsenoside Rg1 attenuates PM2.5-induced neurotoxicity by suppressing ferroptosis via the Nrf2/GPx4 axis
Journal: Journal Of Ethnopharmacology
DOI: 10.1016/j.jep.2026.121464
IF: 5.4
Application: WB
Reactivity: Mouse
Publish date: 2026 Mar
-
Araloside A alleviates sepsis-induced acute lung injury via PHD2/HIF-1α in macrophages.
Journal: Phytomedicine
DOI:
IF: 6.7
Application: WB
Reactivity:
Publish date: 2024 Sep
Alternative Products
COX2 Recombinant Rabbit Monoclonal Antibody [SC56-06]
Application: WB,IF-Cell,IF-Tissue,IHC-P
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
Products with the same target and pathway
COX2 Mouse Monoclonal Antibody [A3F7]
Application: WB,IHC-P,FC
Reactivity: Human,Rat
Conjugate: unconjugated
COX2 Mouse Monoclonal Antibody [A3F8]
Application: WB,IHC-P,FC
Reactivity: Human,Rat
Conjugate: unconjugated
