Chromogranin A Mouse Monoclonal Antibody
Catalog# IRS132MS
Chromogranin A Mouse Monoclonal Antibody
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mIHC
-
Human
-
unconjugated
Overview
Product Name
Chromogranin A Mouse Monoclonal Antibody
Antibody Type
Mouse Monoclonal Antibody
Immunogen
Recombinant protein within human Chromogranin A aa 358-457.
Species Reactivity
Human
Validated Applications
mIHC
Molecular Weight
Predicted band size: 51 kDa
Positive Control
Human pancreas tissue.
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.
Isotype
IgG
Purification Method
Protein G affinity purified.
Application Dilution
-
mIHC
-
1:100
Target
Function
Strongly inhibits glucose induced insulin release from the pancreas.Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa . Can induce mast cell migration, degranulation and production of cytokines and chemokines . Acts as a potent scavenger of free radicals in vitro tion and blood pressure .Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
Background References
1. Briolat J. et. al. New antimicrobial activity for the catecholamine release-inhibitory peptide from chromogranin A. Cell. Mol. Life Sci. 62:377-385(2005).
Subcellular Location
Cytoplasmic vesicle, Secreted.
UNIPROT
Synonyms
beta Granin antibody
betagranin (N-terminal fragment of chromogranin A) antibody
catestatin antibody
CgA antibody
CHG A antibody
Chga antibody
chromofungin antibody
Chromogranin A antibody
Chromogranin A parathyroid secretory protein 1 antibody
Chromogranin A precursor antibody
ExpandImages
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mIHC analysis of human pancreas tissue (Formalin/PFA-fixed paraffin-embedded sections) with Mouse anti-Chromogranin A antibody (IRS132MS) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900809). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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