NFIB / NF1B2 Mouse Monoclonal Antibody [1H5]

Function

NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, α-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.

Background References

1. Liu Y et al. NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing. J Biol Chem 272:10739-10745 (1997).

2. Bechtel S et al. The full-ORF clone resource of the German cDNA consortium. BMC Genomics 8:399-399 (2007).

Sequence Similarity

Belongs to the CTF/NF-I family.

Subcellular Location

Nucleus.

UNIPROT

SwissProt: O00712 Human

SwissProt: P97863 Mouse

Entrez Gene: 29227 Rat

Synonyms