ACY1 Mouse Monoclonal Antibody [15G2] (EM1901-86)

UNIPROT #

Q03154

PROTEIN NAME

ACY1

SYNONYMS

ACY 1 antibody;ACY-1 antibody;Acy1 antibody;ACY1_HUMAN antibody;ACY1D antibody;ACYLASE antibody;Acylase I antibody;Aminoacylase 1 antibody;Aminoacylase-1 antibody;EC 3.5.1.14 antibody;epididymis secretory protein Li 5 antibody;HEL-S-5 antibody;N acyl L amino acid amidohydrolase antibody;N-acyl-L-amino-acid amidohydrolase antibody;OTTHUMP00000212459 antibody;OTTHUMP00000212462 antibody;OTTHUMP00000212463 antibody;OTTHUMP00000212464 antibody;OTTHUMP00000212465 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M20A family.

TISSUE SPECIFICITY

Expression is highest in kidney, strong in brain and weaker in placenta and spleen.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Aminoacylase is involved in the regulation of the urea cycle. N-acetyl-L-glutamate is an allosteric activator of carbamoyl phosphate synthetase, a crucial enzyme that commits NH4+ molecules to the urea cycle. The urea cycle gets rid of excess ammonia (NH4+) in the body, a process that must be up-regulated during times of increased protein catabolism, as amino acid breakdown produces large amounts of NH4+. When amino acid catabolism increases, N-Acetylglutamate synthase is up-regulated, producing more N-acetyl-L-glutamate, which up-regulates carbamoyl phosphate synthetase and allows it to dispose of the excess NH4+ from catabolism.Aminoacylase is up-regulated during times of nutrient deficit or starvation, causing N-acetyl-L-glutamate breakdown, which down-regulates carbamoyl phosphate synthetase and the rest of the urea cycle. This response is evolutionarily advantageous, since a nutrient deficit means there isn't as much NH4+ that needs to be disposed of and since the body wants to salvage as many amino acids as it can.