KV4.3 Rabbit Polyclonal Antibody (ER1802-91)

UNIPROT #

Q9UK17

PROTEIN NAME

KV4.3

SYNONYMS

KCND 3 antibody;KCND 3L antibody;KCND 3S antibody;Kcnd3 antibody;KCND3_HUMAN antibody;KCND3L antibody;KCND3S antibody;KSHIVB antibody;Kv 4.3 antibody;MGC14203 antibody;MGC142037 antibody;OTTHUMP00000063948 antibody;Potassium ioinic channel Kv4.3 antibody;Potassium voltage gated channel Shal related subfamily member 3 antibody;Potassium voltage gated channel subfamily D member 3 antibody;Potassium voltage-gated channel subfamily D member 3 antibody;Sha1 related potassium channel Kv4.3 antibody;Voltage gated K+ channel antibody;Voltage gated potassium channel Kv4.3 antibody;Voltage gated potassium channel subunit Kv4.3 antibody;Voltage-gated potassium channel subunit Kv4.3 antibody

SEQUENCE SIMILARITIES

Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily.

TISSUE SPECIFICITY

Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas.

POST-TRANSLATIONAL MODIFICATION

Regulated through phosphorylation at Ser-569 by CaMK2D.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes – shaker, shaw, shab, and shal – have been identified in Drosophila, and each has been shown to have human homolog(s). Kv4.3 is a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene.