Methyltransferase-like 26 Rabbit Polyclonal Antibody

Function

METTL26, previously designated C16orf13, is a protein-coding gene for Methyltransferase Like 26, also known as JFP2. Though the function of this gene is unknown, various data have revealed that it is expressed at high levels in various cancerous tissues. Underexpression of this gene has also been linked to disease consequences in humans. The human expression profile from NCBI UniGene suggests that this gene has widespread expression in many different tissues in the body. This expression profile suggests that this gene is a “housekeeping gene,” one that has important effects in all cells, regardless of tissue. The highest levels of expression appear to be in the adrenal gland, lung, and parathyroid. There are many additional sites besides these highest three where the gene is expressed in high levels. There seems to be no real similarity in the few tissues where the gene is not expressed. This expression data does not seem to give any clues into specific function, except to suggest that the gene is involved in a “housekeeping” function of nearly all cells. The protein that this gene codes for is known as UPF0585, where UPF signals unknown protein function. There are five isoforms of this protein, corresponding to the five splice variants of the gene. The isoforms are named a, b, c, d, and g As mentioned above, the conserved domain detected in a BLAST search of this amino acid sequence is a methyltransferase superfamily

Background References

1. Oh JH et al. Transcriptome analysis of human gastric cancer. Mamm Genome 16(12):942-54 (2005).

2. The MGC Project Team. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res.14:2121-2127 (2004).

Sequence Similarity

Belongs to the UPF0585 family.

Subcellular Location

Cytoplasm.

UNIPROT

SwissProt: Q96S19 Human

SwissProt: Q9DCS2 Mouse

SwissProt: Q497C3 Rat

Synonyms