SLC29A1 Rabbit Polyclonal Antibody
Catalog# ER1902-43
SLC29A1 Rabbit Polyclonal Antibody
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WB
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IHC-P
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Human
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Mouse
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Rat
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unconjugated
Overview
Product Name
SLC29A1 Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Synthetic peptide of human SLC29A1
Species Reactivity
Human, Mouse, Rat
Validated Applications
WB, IHC-P
Molecular Weight
Predicted band size: 50 kDa
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Store at 4℃ short term. Aliquot and store at -20℃ long term. Avoid freeze/thaw cycles.
Storage Buffer
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Isotype
IgG
Application Dilution
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WB
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1:500-1:2,000
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IHC-P
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1:25-1:100
Target
Function
This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
Background References
1. Mangravite L.M et al. Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. Am. J. Physiol. 284:F902-F910(2003)
Sequence Similarity
Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
Tissue Specificity
Detected in erythrocytes (at protein level). Expressed in heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen.
Post-translational Modification
Glycosylated.
Subcellular Location
Basolateral cell membrane, Apical cell membrane, Cell membrane.
Synonyms
Equilibrative NBMPR-sensitive nucleoside transporter antibody
equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporter antibody
Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter antibody
Equilibrative nucleoside transporter 1 antibody
es-type antibody
MGC1465 antibody
MGC3778 antibody
Nucleoside transporter antibody
Nucleoside transporter, es-type antibody
OTTHUMP00000016506 antibody
ExpandImages
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Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human placenta and normal kidney tissue, Primary antibody: ER1902-43 (SLC29A1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8,000 dilution, Exposure time: 3 minutes
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The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using ER1902-43 (SLC29A1 Antibody) at dilution 1/25. (Original magnification: ×200)
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The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using ER1902-43 (SLC29A1 Antibody) at dilution 1/25. (Original magnification: ×200)
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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