ATP8A1 Rabbit Polyclonal Antibody (ER1902-61)

UNIPROT #

Q9Y2Q0

PROTEIN NAME

ATP8A1

SYNONYMS

Phospholipid-transporting ATPase IA antibody;ATPase class I type 8A member 1 antibody;Chromaffin granule ATPase II antibody;P4-ATPase flippase complex alpha subunit ATP8A1 antibody;ATP8A1 antibody

SEQUENCE SIMILARITIES

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.

TISSUE SPECIFICITY

Found in most adult tissues except liver, testis and placenta. Most abundant in heart, brain and skeletal muscle. Also detected in fetal tissues. Isoform 1 is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal muscle.

SUBCELLULAR LOCATION

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane.

FUNCTION

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells.