KAT3B / p300 Rabbit Polyclonal Antibody

Function

Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap DNA less tightly. This enzyme plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions (differentiate), and preventing the growth of cancerous tumors. The p300 protein appears to be critical for normal development before and after birth.

Background References

1. Nicosia L et al. Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies. Cancer Cell. 2023 Dec

2. Durbin AD et al. EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma. Cancer Discov. 2022 Mar

Subcellular Location

Cytoplasm, Nucleus, Chromosome.

UNIPROT

SwissProt: Q09472 Human

SwissProt: B2RWS6 Mouse

Entrez Gene: 170915 Rat

Synonyms

E1A associated protein p300 antibody

E1A binding protein p300 antibody

E1A-associated protein p300 antibody

EP300 antibody

EP300: E1A binding protein p300 antibody

EP300_HUMAN antibody

Histone acetyltransferase p300 antibody

KAT3B antibody

p300 HAT antibody

RSTS2 antibody