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mSin3A Rabbit Polyclonal Antibody (ER2001-38)

Price: Regular price $315.00

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Catalog# ER2001-38

Rabbit Polyclonal to mSin3A

Tested for

  • WB

Reacts with

  • Human

  • Mouse

  • Rat

Specifications

Product Type

Rabbit polyclonal primary

Product Name

mSin3A Rabbit Polyclonal Antibody (ER2001-38)

Immunogen

Synthetic peptide within human msin3a aa 1-50.

Host

Rabbit

Positive Control

HL-60 cell lysate, A549 cell lysate, Siha cell lysate.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3073455

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

145 kDa

Isotype

IgG

TARGET

UNIPROT #

Q96ST3

PROTEIN NAME

mSin3A

SYNONYMS

AW553200 antibody;DKFZP434K2235 antibody;FLJ90319 antibody;Histone deacetylase complex subunit Sin 3a antibody;Histone deacetylase complex subunit Sin3a antibody;KIAA0700 antibody;Kiaa4126 antibody;mKIAA4126 antibody;Paired amphipathic helix protein Sin 3a antibody;Paired amphipathic helix protein Sin3a antibody;Sin 3a antibody;SIN3 homolog A antibody;SIN3 homolog A transcription regulator (yeast) antibody;SIN3 homolog A transcription regulator antibody;SIN3 transcription regulator homolog A antibody;Sin3a antibody;SIN3A protein antibody;SIN3A_HUMAN antibody;Transcriptional co repressor Sin 3A antibody;Transcriptional co repressor Sin3A antibody;Transcriptional corepressor Sin3a antibody;Transcriptional regulator SIN3A antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). Required for cortical neuron differentiation and callosal axon elongation (By similarity).

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