Transketolase Rabbit Polyclonal Antibody

Function

Transketolase (abbreviated as TK) is an enzyme that, in humans, is encoded by the TKT gene. It participates in both the pentose phosphate pathway in all organisms and the Calvin cycle of photosynthesis. Transketolase catalyzes two important reactions, which operate in opposite directions in these two pathways. In the first reaction of the non-oxidative pentose phosphate pathway, the cofactor thiamine diphosphate accepts a 2-carbon fragment from a 5-carbon ketose (D-xylulose-5-P), then transfers this fragment to a 5-carbon aldose (D-ribose-5-P) to form a 7-carbon ketose (sedoheptulose-7-P). The abstraction of two carbons from D-xylulose-5-P yields the 3-carbon aldose glyceraldehyde-3-P. In the Calvin cycle, transketolase catalyzes the reverse reaction, the conversion of sedoheptulose-7-P and glyceraldehyde-3-P to pentoses, the aldose D-ribose-5-P and the ketose D-xylulose-5-P.

Background References

1. Tong L et al. Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity. Cell Metab. 2024 May

2. Hao S et al. The role of transketolase in human cancer progression and therapy. Biomed Pharmacother. 2022 Oct

Subcellular Location

Cytosol, endoplasmic reticulum membrane, extracellular exosome, nuclear body, nucleoplasm, peroxisome, vesicle.

UNIPROT

SwissProt: P29401 Human

SwissProt: P40142 Mouse

SwissProt: P50137 Rat

Synonyms

EC 2.2.1.1 antibody

FLJ34765 antibody

TK antibody

TKT 1 antibody

tkt antibody

TKT_HUMAN antibody

TKT1 antibody

Transketolase (Wernicke Korsakoff syndrome) antibody

Transketolase antibody