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ARG1 Recombinant Rabbit Monoclonal Antibody [SY09-06] (ET1605-8)

Price: Regular price $385.00

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Catalog# ET1605-8

Rabbit Monoclonal to ARG1

Tested for

  • WB

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

ARG1 Recombinant Rabbit Monoclonal Antibody [SY09-06] (ET1605-8)

Immunogen

Synthetic peptide within human arg1 aa 20-60.

Host

Rabbit

Positive Control

Human liver tissue lysate, Mouse liver tissue lysate, Rat liver tissue lysate, THP-1 treated with 185ng/mL TPA for 54 hours add 20ng/mL hIFN-γ and 100ng/mL LPS for 48 hours cell lysate, RAW264.7 treated with 20ng/mL mIL-4 and 10ng/mL mIL-13 for 24 hours cell lysate.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SY09-06

RRID

AB_3069721

APPLICATION DILUTION

  • WB

  • 1:1,000-1:2,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 35 kDa

Isotype

IgG

TARGET

UNIPROT #

P05089

PROTEIN NAME

ARG1

SYNONYMS

arg1 antibody;ARGI1_HUMAN antibody;Arginase-1 antibody;Liver-type arginase antibody;Type I arginase antibody

SEQUENCE SIMILARITIES

Belongs to the arginase family.

TISSUE SPECIFICITY

Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes [PMNs]). Also detected in macrophages mycobacterial granulomas. Expressed in group2 innate lymphoid cells (ILC2s) during lung disease.

SUBCELLULAR LOCATION

Cytoplasm,Cytoplasmic granule.

FUNCTION

Arginase I (also designated liver-type arginase), which is expressed almost exclusively in the liver, catalyzes the conversion of arginine to ornithine and urea. The human arginase I gene, which maps to chromosome 6q23, encodes a 322 amino acid protein. Arginase I exists as a homotrimeric protein and contains a binuclear manganese cluster. Arginase II catalyzes the same reaction as arginase I, but differs in its tissue specificity and subcellular location. Specifically, arginase II localizes to the mitochondria. Arginase II is expressed in non-hepatic tissues, with the highest levels of expression in the kidneys, but, unlike arginase I, is not expressed in liver. The human arginase II gene, which maps to chromosome 14q24.1-q24.3, encodes a 354 amino acid protein. In addition, arginase II contains a putative amino-terminal mitochondrial localization sequence.

CITATIONS

  • Liang Lu,et al

    Intracellularly Synthesized Artificial Exosome Treats Acute Lung Injury

  • Zhaoyan Chen,et al

    Quercetin alleviates neonatal hypoxic-ischaemic brain injury by rebalancing microglial M1/M2 polarization through silent information regulator 1/ high mobility group box-1 signalling

  • Han Liu , Haiyang Guo , Yuehan Wu , et al

    RCN1 deficiency inhibits oral squamous cell carcinoma progression and THP-1 macrophage M2 polarization

  • Niu Yuzhen,et al

    Paeonol interferes with lupus nephritis by regulating M1/M2 polarization of macrophages

  • Liang, L., Xu, W., Shen, A., Fu, X., Cen, H., Wang, S., Lin, Z., Zhang, L., Lin, F., Zhang, X., Zhou, N., Chang, J., Chen, Z. S., Li, C., & Yu, X.

    Inhibition of YAP1 activity ameliorates acute lung injury through promotion of M2 macrophage polarization

  • He Yining,et al

    Exploration of the underlying mechanism of Astragaloside III in attenuating immunosuppression via network pharmacology and vitro/vivo pharmacological validation

  • Jianguo Xu,and Hong Tan

    Macrophage Polarization in Response to Varying Pore Sizes of 3D Polyurethane Scaffolds

  • Wu Zhihao,et al

    Exploring the Mechanism of Asiatic Acid against Atherosclerosis Based on Molecular Docking, Molecular Dynamics, and Experimental Verification

  • Wang, C., Wei, S., Liu, B., Wang, F., Lu, Z., Jin, M., & Wang, Y.

    Maternal consumption of a fermented diet protects offspring against intestinal inflammation by regulating the gut microbiota

  • He, J., Lin, M., Zhang, X., Zhang, R., Tian, T., Zhou, Y., Dong, W., Yang, Y., Sun, X., Dai, Y., Xu, Y., Zhang, Z., Xu, M., Lei, Q. Y., Xu, Y., & Lv, L.

    TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential

  • Zhang, L., Zhang, X., Liu, Y., Zhang, W., Wu, C. T., & Wang, L.

    CD146+ Umbilical Cord Mesenchymal Stem Cells Exhibit High Immunomodulatory Activity and Therapeutic Efficacy in Septic Mice

  • Dan Wang,et al

    Targeting SphK1/S1PR3 axis ameliorates sepsis-induced multiple organ injury via orchestration of macrophage polarization and glycolysis

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