PI 3 Kinase catalytic subunit alpha Recombinant Rabbit Monoclonal Antibody [SJ0186] (ET1606-36)

UNIPROT #

P42336

PROTEIN NAME

PI 3 Kinase catalytic subunit alpha

SYNONYMS

5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha antibody;5-bisphosphate 3-kinase catalytic subunit alpha isoform antibody;caPI3K antibody;CLOVE antibody;CWS5 antibody;MCAP antibody;MCM antibody;MCMTC antibody;MGC142161 antibody;MGC142163 antibody;p110 alpha antibody;p110alpha antibody;Phosphatidylinositol 3 kinase catalytic alpha polypeptide antibody;Phosphatidylinositol 3 kinase catalytic 110 KD alpha antibody;Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha antibody;Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform antibody;Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha antibody;Phosphatidylinositol-4 antibody;Phosphoinositide 3 kinase catalytic alpha polypeptide antibody;PI3 kinase p110 subunit alpha antibody;PI3-kinase subunit alpha antibody;PI3K antibody;PI3K-alpha antibody;PI3KC A antibody;PIK3C A antibody;Pik3ca antibody;PK3CA antibody;PK3CA_HUMAN antibody;PtdIns 3 kinase p110 antibody;PtdIns-3-kinase subunit alpha antibody;PtdIns-3-kinase subunit p110-alpha antibody;Serine/threonine protein kinase PIK3CA antibody

SEQUENCE SIMILARITIES

Belongs to the PI3/PI4-kinase family.

SUBCELLULAR LOCATION

Cytosol, plasma membrane, cytoplasm, lamellipodium, membrane, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IA.

FUNCTION

Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others. Plays a role in the positive regulation of phagocytosis and pinocytosis.