PI 3 Kinase Class 3 Recombinant Rabbit Monoclonal Antibody [SY0286] (ET1607-74)

UNIPROT #

Q8NEB9

PROTEIN NAME

PI 3 Kinase Class 3

SYNONYMS

hVps34 antibody;MGC61518 antibody;Phosphatidylinositol 3 kinase catalytic subunit type 3 antibody;Phosphatidylinositol 3 kinase class 3 antibody;Phosphatidylinositol 3 kinase p100 subunit antibody;Phosphatidylinositol 3-kinase catalytic subunit type 3 antibody;Phosphatidylinositol 3-kinase p100 subunit antibody;Phosphoinositide 3 kinase class 3 antibody;Phosphoinositide-3-kinase class 3 antibody;PI3 kinase type 3 antibody;PI3-kinase type 3 antibody;PI3K type 3 antibody;Pik3c3 antibody;PK3C3_HUMAN antibody;PtdIns 3 kinase type 3 antibody;PtdIns-3-kinase type 3 antibody;Vps 34 antibody;Vps34 antibody

SEQUENCE SIMILARITIES

Belongs to the PI3/PI4-kinase family.

TISSUE SPECIFICITY

Ubiquitously expressed, with a highest expression in skeletal muscle.

SUBCELLULAR LOCATION

Midbody, Late endosome, Cytoplasmic vesicle.

FUNCTION

Phosphatidylinositol 3-kinase catalytic subunit type 3 is an enzyme subunit that in humans is encoded by the PIK3C3 gene. It's a class III phosphoinositide 3-kinase. It is ubiquitously expressed with predominant expression in skeletal muscle and is believed to participate in endosome to lysosome transport, multivesicular body formation, autophagy and retrograde endosome to Golgi transport. PI 3-kinase p100 is the catalytic subunit of class III PI3Ks and forms a heterodimer with p150, a regulatory subunit of class 3 PI3Ks. PI 3-kinase p100 exclusively phosphorylates phosphatidylinositol to produce PtdIns3P. Unlike class I PI3Ks, whose activities are enhanced in the presence of magnesium, PI 3-kinase p100 activity is enhanced by manganese. Its activity can also be regulated by nutrients, suggesting an important role of PI-3 kinase p100 in the regulation of mTOR protein synthesis and autophagy.