SOX18 Recombinant Rabbit Monoclonal Antibody [ST43-02]

Function

Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. Sox-18 is a 384 amino acid nuclear protein that contains one HMG box DNA-binding domain and belongs to the Sox family of transcriptional regulators.

Background References

1. Petrovic, I. et al. SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines. PloS one 10: e0143591 (2015).

2. Petrovic, I. et al. ZBP-89 and Sp3 down-regulate while NF-Y up-regulates SOX18 promoter activity in HeLa cells. Molecular biology reports 36: 993-1000 (2009).

Tissue Specificity

Detected in heart, lung, placenta, skeletal muscle, liver, kidney, spleen, prostate, ovary, msosmall intestine and colon.

Subcellular Location

Nucleus.

UNIPROT

SwissProt: P35713 Human

SwissProt: P43680 Mouse

SwissProt: Q4V7E4 Rat

Synonyms

HLTS antibody

SOX 18 antibody

Sox18 antibody

SOX18_HUMAN antibody

SRY (sex determining region Y) box 18 antibody

SRY box 18 antibody

Transcription factor SOX 18 antibody

Transcription factor SOX-18 antibody