Angiopoietin 1 Recombinant Rabbit Monoclonal Antibody [SN67-02] (ET1611-28)

UNIPROT #

Q15389

PROTEIN NAME

Angiopoietin 1

SYNONYMS

AGP 1 antibody;AGP1 antibody;AGPT antibody;ANG 1 antibody;ANG antibody;ANG-1 antibody;ANG1 antibody;Angiopoietin-1 antibody;Angiopoietin1 antibody;ANGP1_HUMAN antibody;ANGPT 1 antibody;Angpt1 antibody;KIAA0003 antibody;OTTHUMP00000227592 antibody;OTTHUMP00000227599 antibody;OTTHUMP00000227600 antibody

POST-TRANSLATIONAL MODIFICATION

Glycosylated.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1. Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. During pregnancy, angiopoietins act complementary to the VEGF system and contribute to endothelial cell survival and the remodeling of vessels. Few studies have examined the role of angiopoietins in human pregnancy complications like preeclampsia and intrauterine growth restriction (IUGR).