Cyclin H Recombinant Rabbit Monoclonal Antibody [SN20-48] (ET1611-84)

UNIPROT #

P51946

PROTEIN NAME

Cyclin H

SYNONYMS

6330408H09Rik antibody;AI661354 antibody;AV102684 antibody;AW538719 antibody;CAK antibody;CAK complex subunit antibody;ccnh antibody;CCNH_HUMAN antibody;CDK activating kinase antibody;CDK activating kinase complex subunit antibody;Cyclin dependent kinase activating kinase antibody;cyclin dependent kinase activating kinase complex subunit antibody;Cyclin H antibody;Cyclin-H antibody;CyclinH antibody;MO15 associated protein antibody;MO15-associated protein antibody;p34 antibody;p36 antibody;p37 antibody

SEQUENCE SIMILARITIES

Belongs to the cyclin family. Cyclin C subfamily.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Progression through the cell cycle requires activation of a series of enzymes designated cyclin dependent kinases (Cdks). The monomeric catalytic subunit, Cdk2, a critical enzyme for initiation of cell cycle progression, is completely inactive. Partial activation is achieved by the binding of regulatory cyclins such as cyclin D1, while full activation requires, in addition, phosphorylation at Thr-160. The enzyme responsible for phosphorylation of Thr-160 in Cdk2 and also Thr-161 in Cdc2 p34, designated Cdk-activating kinase (CAK), has been partially purified and shown to be comprised of a catalytic subunit and a regulatory subunit. The catalytic subunit, designated Cdk7, has been identified as the mammalian homolog of MO15, a protein kinase demonstrated earlier in starfish and Xenopus. The regulatory subunit is a novel cyclin (cyclin H) and is required for activation of Cdk7. Like other Cdks, Cdk7 contains a conserved threonine required for full activity; mutation of this residue severely reduces CAK activity.