Calnexin Recombinant Rabbit Monoclonal Antibody [SN20-54] (ET1611-86)

UNIPROT #

P27824

PROTEIN NAME

Calnexin

SYNONYMS

Calnexin antibody;CALX_HUMAN antibody;CANX antibody;CNX antibody;FLJ26570 antibody;Histocompatibility complex class I antigen binding protein p88 antibody;IP90 antibody;Major histocompatibility complex class I antigen-binding protein p88 antibody;p90 antibody

SEQUENCE SIMILARITIES

Belongs to the calreticulin family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).; Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins.; Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane, Endoplasmic reticulum, Melanosome.

FUNCTION

Calnexin and Calregulin (also called calreticulin) are calcium-binding proteins that are localized to the endoplasmic reticulum, Calnexin to the membrane and Calregulin to the lumen. Calnexin is a type I membrane protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may play a role in assisting with protein assembly and in retaining unassembled protein subunits in the endoplasmic reticulum. Calregulin has both low- and high-affinity calcium-binding sites. Neither Calnexin nor Calregulin contains the calcium-binding “E-F hand” motif found in calmodulins. Calnexin and Calregulin are important for the maturation of glycoproteins in the endoplasmic reticulum and appear to bind many of the same proteins.