SOX10 Recombinant Rabbit Monoclonal Antibody [SN20-41]
Catalog# ET1611-89
SOX10 Recombinant Rabbit Monoclonal Antibody [SN20-41]
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WB
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Human
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Mouse
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Rat
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unconjugated
Overview
Product Name
SOX10 Recombinant Rabbit Monoclonal Antibody [SN20-41]
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Synthetic peptide within Human SOX10 aa 400-450 / 466.
Species Reactivity
Human, Mouse (Predicted: Rat)
Predicted species support after-sales service
Validated Applications
WB
Target Molecular Weight
Predicted band size: 50 kDa
Positive Control
SK-MEL-28 cell lysate, B16-F1 cell lysate, A375 cell lysate.
Conjugation
unconjugated
Clone Number
SN20-41
RRID
Product Features
Form
Liquid
Concentration
1 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
WB
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1:5,000
Target
Function
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
Background References
1. Pingault V et al. SOX10: 20 years of phenotypic plurality and current understanding of its developmental function. J Med Genet. 2022 Feb
2. Yoon EC et al. TRPS1, GATA3, and SOX10 expression in triple-negative breast carcinoma. Hum Pathol. 2022 Jul
Tissue Specificity
Expressed in fetal brain and in adult brain, heart, small intestine and colon.
Subcellular Location
Cytoplasm, Nucleus, Mitochondrion outer membrane.
Synonyms
DOM antibody
DOM antibody
Dominant megacolon mouse human homolog of antibody
MGC15649 antibody
PCWH antibody
SOX 10 antibody
SOX10 antibody
SOX10_HUMAN antibody
SRY (sex determining region Y) box 10 antibody
SRY (sex determining region Y) box 10 antibody
ExpandImages
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Western blot analysis of SOX10 on different lysates with Rabbit anti-SOX10 antibody (ET1611-89) at 1/5,000 dilution.
Lane 1: SK-MEL-28 cell lysate
Lane 2: B16-F1 cell lysate
Lane 3: A375 cell lysate
Lysates/proteins at 15 µg/Lane.
Predicted band size: 50 kDa
Observed band size: 55/75 kDa
Exposure time: 5 minutes 10 seconds;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (ET1611-89) at 1/5,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Products with the same target and pathway
SOX10 Recombinant Rabbit Monoclonal Antibody [PDH0-03]
Application: WB,IHC-P,IF-Cell,IF-Tissue,FC,IHC-Fr,IP
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Conjugate: unconjugated
SOX10 Recombinant Rabbit Monoclonal Antibody [PDH0-04]
Application: WB,IHC-P,IF-Cell,IF-Tissue,FC
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
SOX10 Recombinant Rabbit Monoclonal Antibody [PDH0-05]
Application: WB,IHC-P,IF-Cell,IF-Tissue,FC,IP
Reactivity: Human,Mouse,Rat
Conjugate: unconjugated
SOX10 Rabbit Polyclonal Antibody
Application: WB,IHC-P
Reactivity: Human,Mouse
Conjugate: unconjugated
