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Cyclin A2 Recombinant Rabbit Monoclonal Antibody [SD2052] (ET1612-26)

Price: Regular price $385.00

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Catalog# ET1612-26

Rabbit Monoclonal to Cyclin A2

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Cyclin A2 Recombinant Rabbit Monoclonal Antibody [SD2052] (ET1612-26)

Immunogen

Recombinant protein within mouse cyclin a2 aa 1-240 / 422.

Host

Rabbit

Positive Control

HeLa cell lysate, HCT 116 cell lysate, Jurkat cell lysate, NIH/3T3 cell lysate, RAW264.7 cell lysate, C6 cell lysate, MCF-7 cell lysate, HeLa, human tonsil tissue, mouse testis tissue, rat testis tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SD2052

RRID

AB_3070099

APPLICATION DILUTION

  • WB

  • 1:2,000

  • IF-Cell

  • 1:100-1:500

  • IF-Tissue

  • 1:100-1:500

  • IHC-P

  • 1:1,000-1:10,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 49 kDa

Isotype

IgG

TARGET

UNIPROT #

P20248

PROTEIN NAME

Cyclin A2

SYNONYMS

CCN1 antibody;CCNA antibody;Ccna2 antibody;CCNA2_HUMAN antibody;Cyclin A2 antibody;Cyclin-A antibody;Cyclin-A2 antibody

SEQUENCE SIMILARITIES

Belongs to the cyclin family. Cyclin AB subfamily.

DEVELOPMENTAL STAGE

Accumulates steadily during G2 and is abruptly destroyed at mitosis. Not detected during the G1 phase of the cell cycle. It accumulates during the DNA synthesis/S phase and disappears as cells progress into mitosis, between prophase and metaphase (at protein level).

POST-TRANSLATIONAL MODIFICATION

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

The critical role that the family of regulatory proteins known as cyclins play in eukaryotic cell cycle regulation is well established. The best-characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of maturing promoting factor. Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin- dependent kinase-2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DRTF1 and E2F and retinoblastoma protein, p110. A second form of cyclin A, named cyclin A1 because of its high sequence homology to Xenopus cyclin A1, is most highly expressed in germ cells. It has been proposed that cyclin A1 can associate with Cdk2, p39 and Cdc2 p34.

CITATIONS

  • Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice

  • Prolactin-Responsive Circular RNA circHIPK3Promotes Proliferation of Mammary Epithelial Cellsfrom Dairy Cow

  • Dou, W., Xie, J., Chen, J., Zhou, J., Xu, Z., Wang, Z., & Zhu, Q.

    Overexpression of adrenomedullin (ADM) alleviates the senescence of human dental pulp stem cells by regulating the miR-152/CCNA2 pathway

  • Chinese Propolis Inhibits the Proliferation of Human Gastric Cancer Cells by Inducing Apoptosis and Cell Cycle Arrest

  • Cui Hongjuan,et al

    RNF181 promotes ferroptosis by ubiquitinating HMOX1 to inhibit gastric cancer cell proliferation and chemoresistance

  • Lei Tao,et al

    Hydrochlorothiazide disrupts DNA damage response to exacerbate skin photosensitivity

  • Astaxanthin Prevents Tuberculosis-Associated Inflammatory Injury by Inhibiting the Caspase 4/11-Gasdermin-Pyroptosis Pathway

  • Eriocalyxin B Inhibits Adipogenesis in 3T3‑L1 Adipocytes by Cell Cycle Arrest

  • Zhou Yuanyuan,et al

    The Role of DNA Damage Response in Human Embryonic Stem Cells Exposed to Atmospheric Oxygen Tension: Implications for Embryo Development and Differentiation

  • Liandi Guo;Jie Chen; Cong Liu

    Cell type-specific genotoxicity in estrogenexposed ovarian and fallopian epithelium

  • Cao, X., Shu, Y., Chen, Y., Xu, Q., Guo, G., Wu, Z., Shao, M., Zhou, Y., Chen, M., Gong, Y., Li, C., Shi, Y., & Bu, H.

    Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis. Cellular and molecular gastroenterology and hepatology, S2352-345X(21)00072-2. Advance online publication.

  • Zhengzheng Li;Zhiting Wang

    Canagliflozin impairs blood reperfusion of ischaemic lower limb partially by inhibiting the retention and paracrine function of bone marrow derived mesenchymal stem cells

  • Liu, X., Cui, S., Dan, C., Li, W., Xie, H., Li, C., & Shi, L.

    Phellinus baumii Polyphenol: A Potential Therapeutic Candidate against Lung Cancer Cells

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