pro Caspase-7 Recombinant Rabbit Monoclonal Antibody [SD20-57] (ET1612-28)

UNIPROT #

P55210

PROTEIN NAME

pro Caspase-7

SYNONYMS

Caspase7;apoptosis-related cysteine peptidase antibody;Apoptotic protease Mch-3 antibody;CASP-7 antibody;CASP7 antibody;CASP7_HUMAN antibody;Caspase-7 subunit p11 antibody;Caspase-7 antibody;Caspase 7 antibody;Caspase7 antibody;CMH-1 antibody;ICE-LAP3 antibody;ICE-like apoptotic protease 3 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C14A family.

TISSUE SPECIFICITY

Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.

POST-TRANSLATIONAL MODIFICATION

Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

A unique family of Cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.