IRF6 Recombinant Rabbit Monoclonal Antibody [SD202-6]

Function

Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-α and β) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-α and interferon-β genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3γ p48 and IFN consensus sequence-binding protein (ICSBP).

Background References

1. Pan Y et al. IRF6 polymorphisms are associated with nonsyndromic orofacial clefts in a Chinese Han population. Am J Med Genet A 152A:2505-11 (2010).

2. Ratovitski, EA. et al. 2011. ΔNp63α/IRF6 interplay activates NOS2 transcription and induces autophagy upon tobacco exposure. Arch. Biochem. Biophys.. 506: 208-215.

Sequence Similarity

Belongs to the IRF family.

Tissue Specificity

Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas.

Post-translational Modification

Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation.

Subcellular Location

Nucleus, Cytoplasm.

UNIPROT

SwissProt: O14896 Human

SwissProt: P97431 Mouse

Entrez Gene: 364081 Rat

Synonyms