HDAC7 Recombinant Rabbit Monoclonal Antibody [SD082-4] (ET1612-67)

UNIPROT #

Q8WUI4

PROTEIN NAME

HDAC7

SYNONYMS

DKFZP586J0917 antibody;FLJ99588 antibody;HD 7a antibody;HD7 antibody;HD7a antibody;HDAC 7 antibody;HDAC 7A antibody;Hdac7 antibody;HDAC7_HUMAN antibody;HDAC7A antibody;Histone deacetylase 7 antibody;Histone deacetylase 7A antibody;OTTHUMP00000202813 antibody;OTTHUMP00000202814 antibody

SEQUENCE SIMILARITIES

Belongs to the histone deacetylase family. HD type 2 subfamily.

POST-TRANSLATIONAL MODIFICATION

May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-181.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1, and the TFIID subunit TAF II p250. Mammalian HDAC7 is a histone deacetylase that interacts with the adaptor mSin3A. The interaction of HDAC7 with mSin3A suggests the association of multiple repression complexes of transcription factors.