CDC23 Recombinant Rabbit Monoclonal Antibody [SD08-60]

Function

Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene. The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.

Background References

1. Achari C et al. Expression of miR-34c induces G2/M cell cycle arrest in breast cancer cells. BMC Cancer 14:538 (2014).

2. Sako K et al. Emi2 mediates meiotic MII arrest by competitively inhibiting the binding of Ube2S to the APC/C. Nat Commun 5:3667 (2014).

Sequence Similarity

Belongs to the APC8/CDC23 family.

Post-translational Modification

Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis.

Subcellular Location

Cytosol.

UNIPROT

SwissProt: Q9UJX2 Human

SwissProt: Q8BGZ4 Mouse

Unigene: 139314 Rat

Synonyms