Integrin alpha 5 Recombinant Rabbit Monoclonal Antibody [JJ08-94] (ET1701-58)

UNIPROT #

P08648

PROTEIN NAME

Integrin alpha 5

SYNONYMS

CD49 antigen-like family member E antibody;CD49e antibody;Fibronectin receptor subunit alpha antibody;Fibronectin receptor, alpha subunit antibody;FNRA antibody;Integrin alpha 5 (fibronectin receptor alpha) antibody;Integrin alpha-5 antibody;Integrin alpha-5 light chain antibody;Integrin alpha-F antibody;Integrin, alpha 5 (fibronectin receptor, alpha polypeptide) antibody;ITA5_HUMAN antibody;Itga5 antibody;Very late activation protein 5, alpha subunit antibody;VLA-5 antibody;VLA5 antibody;VLA5A antibody

SEQUENCE SIMILARITIES

Belongs to the integrin alpha chain family.

POST-TRANSLATIONAL MODIFICATION

Proteolytic cleavage by PCSK5 mediates activation of the precursor.

SUBCELLULAR LOCATION

Membrane, Cell junction, Cell surface.

FUNCTION

Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16 α and 8 β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.