SUZ12 Recombinant Rabbit Monoclonal Antibody [JJ09-04] (ET1701-62)

UNIPROT #

Q15022

PROTEIN NAME

SUZ12

SYNONYMS

ChET 9 protein antibody;CHET9 antibody;Chromatin precipitated E2F target 9 protein antibody;JJAZ1 antibody;Joined to JAZF1 protein antibody;KIAA0160 antibody;Polycomb protein SUZ12 antibody;Suppressor of zeste 12 homolog antibody;Suppressor of zeste 12 protein homolog antibody;SUZ12 antibody;SUZ12 polycomb repressive complex 2 subunit antibody;SUZ12_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.

TISSUE SPECIFICITY

Overexpressed in breast and colon cancer.

DEVELOPMENTAL STAGE

Expressed at low levels in quiescent cells. Expression rises at the G1/S phase transition.

POST-TRANSLATIONAL MODIFICATION

Sumoylated, probably by PIAS2.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The Polycomb group (PcG) genes contribute to the maintenance of cell identity, cell cycle regulation and oncogenesis. The mammalian PcG proteins are regulatory proteins important for Hox gene expression, axial skeleton development and the control of proliferation and survival of hematopoietic cells. By inducing changes in chromatin structure, the PcG proteins are part of a cellular memory system that is responsible for gene activity being inherited to progeny cells. PcG proteins silence gene expression through the formation of multimeric protein complexes with different compositions. Manipulating the expression-levels of various PcG proteins in mammalian cell lines results in cellular transformation, which may be a link between the chromatin-associated PcG proteins and cancer. Polycomb protein SUZ12, also designated ChET 9 protein or joined-to-JAZF1 protein, is a nuclear protein belonging to the VEFS (VRN2-EMF2-FIS2-SUZ12) family. SUZ12 has been detected at the breakpoints of a certain recurrent chromosomal translocation which has been reported in endometrial stromal sarcoma. It is a component of the PRC2 complex, composed of EED, EZH2, SUZ12/JJAZ1, RBBP4 and RBBP7.