ATP5A1 Recombinant Rabbit Monoclonal Antibody [JM110-04] (ET1703-53)

UNIPROT #

P25705

PROTEIN NAME

ATP5A1

SYNONYMS

ATP synthase alpha chain, mitochondrial antibody;ATP synthase subunit alpha antibody;ATP synthase subunit alpha mitochondrial antibody;ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle antibody;ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, 1 antibody;ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle antibody;ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non-cardiac muscle-like 2 antibody;ATP sythase (F1 ATPase) alpha subunit antibody;ATP5A antibody;Atp5a1 antibody;ATP5AL2 antibody;ATPA_HUMAN antibody;ATPM antibody;Epididymis secretory sperm binding protein Li 123m antibody;hATP1 antibody;HEL-S-123m antibody;MC5DN4 antibody;mitochondrial antibody;Mitochondrial ATP synthetase antibody;Mitochondrial ATP synthetase oligomycin resistant antibody;Modifier of Min 2 mouse homolog antibody;Modifier of Min 2, mouse, homolog of antibody;MOM2 antibody;OMR antibody;ORM antibody;OTTHUMP00000163475 antibody

SEQUENCE SIMILARITIES

Belongs to the ATPase alpha/beta chains family.

TISSUE SPECIFICITY

Fetal lung, heart, liver, gut and kidney. Expressed at higher levels in the fetal brain, retina and spinal cord.

POST-TRANSLATIONAL MODIFICATION

The N-terminus is blocked.; Acetylated on lysine residues. BLOC1S1 is required for acetylation.

SUBCELLULAR LOCATION

Mitochondrion, Mitochondrion inner membrane, Cell membrane.

FUNCTION

Mitochondrial ATP synthases (ATPases) transduce the energy contained in membrane electrochemical proton gradients into the energy required for synthesis of high-energy phosphate bonds. ATPases contain two linked complexes: F1, the hydrophilic catalytic core; and F0, the membrane-embedded protein channel. F1 consists of three α chains and three β chains, which are weakly homologous, as well as one γ chain, one δ chain and one e chain. F0 consists of three subunits: a, b and c. The α chain of F1 is a regulatory subunit that contains 509 amino acids. Mitochondrial ATPase α chain (ATP5A) localizes to the mitochondria and catalyzes ATP synthesis.