VCP Recombinant Rabbit Monoclonal Antibody [JM11-15] (ET1703-56)

UNIPROT #

P55072

PROTEIN NAME

VCP

SYNONYMS

15S Mg(2+) ATPase p97 subunit antibody;15S Mg(2+)-ATPase p97 subunit antibody;ALS14 antibody;ATPase p97 antibody;CDC48 antibody;IBMPFD antibody;MGC131997 antibody;MGC148092 antibody;MGC8560 antibody;p97 antibody;TER ATPase antibody;TERA antibody;TERA_HUMAN antibody;Transitional endoplasmic reticulum ATPase antibody;Valosin containing protein antibody;Valosin-containing protein antibody;VCP antibody;Yeast Cdc48p homolog antibody

SEQUENCE SIMILARITIES

Belongs to the AAA ATPase family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by tyrosine kinases in response to T-cell antigen receptor activation. Phosphorylated in mitotic cells.; ISGylated.; Methylation at Lys-315 catalyzed by VCPKMT is increased in the presence of ASPSCR1. Lys-315 methylation may decrease ATPase activity.

SUBCELLULAR LOCATION

Cytoplasm, Endoplasmic reticulum, Nucleus.

FUNCTION

Valosin containing protein (VCP), also designated TERA (for transitional endoplasmic reticulum ATPase) or p97, is a member of the AAA family of ATPases, which are involved in a variety of cellular activities. VCP is the mammalian homolog of Saccharomyces cerevisiae Cdc48, a protein essential for the completion of mitiosis in yeast. VCP is thought to be involved in a variety of membrane functions and in the regulation of the cell cycle. It associates with ubiquitinated IκB-α as well as with the 26S Proteosome, indicating a potential role for VCP in the proteosome-mediated degradation of IκB-α.