CD18 Recombinant Rabbit Monoclonal Antibody [JM71-31]

Function

Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

Background References

1. Sawhney S et al. Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a 133p53a mimic. PLoS One 10:e0116270 (2015).

2. Xiang Y et al. Analysis on the relevance of asthma susceptibility with the alteration of integrin 4 expression. PLoS One 9:e95533 (2014).

Sequence Similarity

Belongs to the integrin beta chain family.

Tissue Specificity

Leukocytes. Expressed in neutrophils (at protein level).

Post-translational Modification

Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.

Subcellular Location

Membrane.

UNIPROT

SwissProt: P05107 Human

Synonyms