EGF Recombinant Rabbit Monoclonal Antibody [JA14-15] (ET1704-33)

UNIPROT #

P01133

PROTEIN NAME

EGF

SYNONYMS

Beta urogastrone antibody;beta-urogastrone antibody;EGF antibody;EGF_HUMAN antibody;Epidermal growth factor antibody;HOMG4 antibody;OTTHUMP00000219721 antibody;OTTHUMP00000219722 antibody;Pro epidermal growth factor antibody;URG antibody;Urogastrone antibody

TISSUE SPECIFICITY

Expressed in kidney, salivary gland, cerebrum and prostate.

POST-TRANSLATIONAL MODIFICATION

O-glycosylated with core 1-like and core 2-like glycans. It is uncertain if Ser-954 or Thr-955 is O-glycosylated. The modification here shows glycan heterogeneity: HexHexNAc (major) and Hex2HexNAc2 (minor).

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Epidermal growth factor (EGF) is an acid- and heat-stable 53 amino acid protein originally found in rodents and humans. It has been shown to be a potent mitogen for a variety of cell types both in vivo and in vitro. EGF binds to the EGF receptor on the surface of cells and mediates intrinsic phosphorylation of the receptor on tyrosine residues. It has been detected in nearly all body fluids, such as urine (urogastrone), saliva, milk and platelet-rich plasma. EGF, TGFα and vaccinia virus growth factor exhibit 30-40% amino acid homology. Several additional members of the EGF/TGF family have been described; these include Cripto, Amphiregulin and the heparin-binding EGF-like growth factor. Amphiregulin and the heparin-binding EGF-like growth factor both bind to the EGF receptor.