Periostin Recombinant Rabbit Monoclonal Antibody [JA63-40] (ET1704-65)

UNIPROT #

Q15063

PROTEIN NAME

Periostin

SYNONYMS

Fasciclin-I like antibody;MGC119510 antibody;MGC119511 antibody;OSF 2 antibody;OSF-2 antibody;OSF2 antibody;Osteoblast specific factor 2 (fasciclin I like) antibody;Osteoblast specific factor 2 antibody;Osteoblast specific factor antibody;Osteoblast-specific factor 2 antibody;PDLPOSTN antibody;Periodontal ligament specific periostin antibody;Periostin antibody;Periostin isoform thy2 antibody;Periostin isoform thy4 antibody;Periostin isoform thy6 antibody;Periostin isoform thy8 antibody;Periostin osteoblast specific factor antibody;PN antibody;POSTN antibody;POSTN_HUMAN antibody;RP11 412K4.1 antibody

TISSUE SPECIFICITY

Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers.

POST-TRANSLATIONAL MODIFICATION

Gamma-carboxylation is controversial. Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; this may be required for calcium binding. According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues.

SUBCELLULAR LOCATION

Golgi apparatus, Secreted, extracellular space, extracellular matrix.

FUNCTION

Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta and alpha(V)beta integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor β 1(TGF β 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.