CD146 Recombinant Rabbit Monoclonal Antibody [JB42-35] (ET7107-91)

UNIPROT #

P43121

PROTEIN NAME

CD146

SYNONYMS

A32 antigen antibody;CD 146 antibody;CD146 antibody;CD146 antigen antibody;Cell surface glycoprotein MUC18 antibody;Cell surface glycoprotein P1H12 antibody;Gicerin antibody;Mcam antibody;Melanoma adhesion molecule antibody;Melanoma associated antigen A32 antibody;Melanoma associated antigen MUC18 antibody;Melanoma associated glycoprotein MUC18 antibody;Melanoma cell adhesion molecule antibody;Melanoma-associated antigen A32 antibody;Melanoma-associated antigen MUC18 antibody;MelCAM antibody;MUC 18 antibody;MUC18 antibody;MUC18_HUMAN antibody;S endo 1 antibody;S endo 1 endothelial associated antigen antibody;S-endo 1 endothelial-associated antigen antibody

TISSUE SPECIFICITY

Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

The tumorigenic and metastatic phenotype of melanoma cells correlates well with an increased expression of cell-cell and cell-matrix adhesion receptors. The human Mel-CAM gene encodes a transmembrane glycoprotein, also designated MCAM, MUC18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. The deduced human sequence of 603 amino acids consists of a signal peptide, five immunoglobulin-like domains, a transmembrane region and a short cytoplasmic tail. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human mela-nomas and correlates well with development of metastatic disease. Mel-CAM activation initiates an outside-in signaling pathway that involves the protein tyrosine kinases Fyn, FAK and paxillin. Mel-CAM influences the dynamics of Actin cytoskeleton rearrangement and is essential for the maintenance of thymic architecture and function.