Ube2N Recombinant Rabbit Monoclonal Antibody [JG38-68] (ET7108-75)

UNIPROT #

P61088

PROTEIN NAME

Ube2N

SYNONYMS

Bendless like ubiquitin conjugating enzyme antibody;Bendless-like ubiquitin-conjugating enzyme antibody;BLU antibody;EC 6.3.2.19 antibody;Epididymis secretory protein Li 71 antibody;HEL-S-71 antibody;Human epidermoid carcinoma mRNA for ubiquitin-conjugating enzyme E2 similar to Drosophila bendless gene product complete cds antibody;MGC131857 antibody;MGC8489 antibody;UBC 13 antibody;Ubc13 antibody;UbCH ben antibody;UbcH-ben antibody;UbcH13 antibody;UBCHBEN antibody;Ube 2N antibody;Ube2n antibody;UBE2N_HUMAN antibody;Ubiquitin carrier protein N antibody;Ubiquitin conjugating enzyme E2 N antibody;Ubiquitin conjugating enzyme E2N (homologous to yeast UBC13) antibody;Ubiquitin conjugating enzyme E2N (UBC13 homolog yeast) antibody;Ubiquitin conjugating enzyme E2N antibody;Ubiquitin protein ligase N antibody;Ubiquitin-conjugating enzyme E2 N antibody;Ubiquitin-protein ligase N antibody;Yeast UBC13 homolog antibody

SEQUENCE SIMILARITIES

Belongs to the ubiquitin-conjugating enzyme family.

POST-TRANSLATIONAL MODIFICATION

Conjugation to ISG15 impairs formation of the thioester bond with ubiquitin but not interaction with UBE2V2.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

Ube2N, a member of the E2 Ubiquitin-conjugating enzyme family, completes the second step of ubiquitination reactions, essentially targeting proteins for proteasomic degradation. When proteins are modified with ubiquitin in an important cellular mechanism targeting abnormal or short lived proteins, ubiquitin, a short protein of 76 amino acids, attaches to a lysine residue resting on the target protein. Multiple cycles of ubiquitination create a polyubiquitin chain that the proteasome recognizes and subsequently triggers the ATP-dependent unfolding of the target protein. This allows protoeolytic degradation of the target protein. These degradation products are highly expressed in heart and skeletal muscles. Ube2N moderates the transcriptional activation of target genes, affects the progress of cell differentiation and aging, and also influences the DNA repair pathway, further adding to the survival of cells after DNA damage.