PEN2 Recombinant Rabbit Monoclonal Antibody [JE41-28] (ET7109-26)

UNIPROT #

Q9NZ42

PROTEIN NAME

PEN2

SYNONYMS

Gamma secretase subunit PEN 2 antibody;Gamma Secretase Subunit PEN2 antibody;Gamma-secretase subunit PEN-2 antibody;Hematopoietic stem/progenitor cells protein MDS033 antibody;MDS033 antibody;MSTP064 antibody;PEN 2 antibody;PEN2_HUMAN antibody;Presenilin Enhancer 2 antibody;Presenilin enhancer 2 homolog antibody;Presenilin enhancer protein 2 antibody;PSEN2 antibody;psenen antibody

SEQUENCE SIMILARITIES

Belongs to the PEN-2 family.

TISSUE SPECIFICITY

Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.

SUBCELLULAR LOCATION

Cell membrane. Endoplasmic reticulum. Golgi apparatus.

FUNCTION

Four proteins comprise the gamma-secretase complex: presenilin, nicastrin, aph-1, and PEN-2. Together, these proteins mediate cell surface signaling pathways for a variety of type I membrane proteins, notably amyloid-beta precursor protein, a protein implicated in the development of Alzheimer's disease, via intramembrane proteolysis. The proteins assemble into a proteolytically active complex in the golgi/trans-golgi network (TGN) compartments. Assembly leads to autocleavage of presenilin into two subunits to create the active site of gamma-secretase, an important step in understanding the mechanisms involved in the etiology and possible treatment of Alzheimer's disease.