WRN Recombinant Rabbit Monoclonal Antibody [JE52-72] (ET7110-26)

UNIPROT #

Q14191

PROTEIN NAME

WRN

SYNONYMS

DKFZp686C2056 antibody;DNA helicase antibody;DNA helicase, RecQ like type 3 antibody;Exonuclease WRN antibody;HGNC 12791 antibody;OTTHUMP00000225301 antibody;RecQ protein-like 2 antibody;RecQ-like type 3 antibody;RecQ3 antibody;RECQL2 antibody;RECQL3 antibody;Werner syndrome ATP-dependent helicase antibody;Werner syndrome helicase antibody;Werner syndrome protein antibody;Werner syndrome, RecQ helicase like antibody;WRN antibody;WRN_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the helicase family. RecQ subfamily.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by PRKDC.

SUBCELLULAR LOCATION

Nucleolus, nucleus, nucleoplasm.

FUNCTION

Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.