RPL7A Recombinant Rabbit Monoclonal Antibody [JE54-45]

Function

60S ribosomal protein L7a is a protein that in humans is encoded by the RPL7A gene.Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Background References

1. Palumbo RJ. et. al. Paralog-Specific Functions of RPL7A and RPL7B Mediated by Ribosomal Protein or snoRNA Dosage in Saccharomyces cerevisiae. G3 (Bethesda). 2017 Feb.

2. Colombo P. et. al. Functional elements of the ribosomal protein L7a (rpL7a) gene promoter region and their conservation between mammals and birds. Nucleic Acids Res. 1992 Jul.

Sequence Similarity

Belongs to the eukaryotic ribosomal protein eL8 family.

Subcellular Location

Cytosol, cytosolic large ribosomal subunit, nucleolus, nucleus, cytoplasm, focal adhesion, membrane, polysomal ribosome, synapse.

UNIPROT

SwissProt: P62424 Human

SwissProt: P12970 Mouse

Synonyms