FPR2 Rabbit Polyclonal Antibody

Function

N-formyl peptide receptor 2 (FPR2) is a G-protein coupled receptor (GPCR) located on the surface of many cell types of various animal species. The human receptor protein is encoded by the FPR2 gene and is activated to regulate cell function by binding any one of a wide variety of ligands including not only certain N-Formylmethionine-containing oligopeptides such as N-Formylmethionine-leucyl-phenylalanine (FMLP) but also the polyunsaturated fatty acid metabolite of arachidonic acid, lipoxin A4 (LXA4). Because of its interaction with lipoxin A4, FPR2 is also commonly named the ALX/FPR2 or just ALX receptor. The FPR2 receptor is expressed on human neutrophils, eosinophils, monocytes, macrophages, T cells, synovial fibroblasts, and intestinal and airway epithelium.

Background References

1. Grimwood J., et al. The DNA sequence and biology of human chromosome 19. Nature 428:529-535(2004).

2. Ota T., et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 36:40-45(2004).

Sequence Similarity

Belongs to the G-protein coupled receptor 1 family.

Tissue Specificity

Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.

Subcellular Location

Cell membrane.

UNIPROT

SwissProt: P25090 Human

SwissProt: O88536 Mouse

Synonyms