FYN Mouse Monoclonal Antibody [D2-A10]

Function

By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility, and adhesion. Src-family kinases contain an amino terminal cell membrane anchor followed by an SH3 domain and an SH2 domain involved in modular association and activation, respectively. Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking. Fyn and Lck kinases play a key role in T-cell antigen receptor (TCR) signaling. The human Fyn gene maps to chromosome 6q21 and encodes a 537 amino acid protein.

Background References

1. Chavez-Solano M et al. Fyn kinase genetic ablation causes structural abnormalities in mature retina and defective Müller cell function. Mol Cell Neurosci 72: 91-100 (2016).

2. Hao L et al. Neuroprotective Effects of Inhibiting Fyn S-Nitrosylation on Cerebral Ischemia/Reperfusion-Induced Damage to CA1 Hippocampal Neurons. Int J Mol Sci 17 (2016).

Subcellular Location

Cell membrane.

UNIPROT

SwissProt: P06241 Human

Synonyms