GDF15 Recombinant Rabbit Monoclonal Antibody [JE39-90]
Catalog# HA722551
GDF15 Recombinant Rabbit Monoclonal Antibody [JE39-90]
-
WB
-
Human
-
unconjugated
Overview
Product Name
GDF15 Recombinant Rabbit Monoclonal Antibody [JE39-90]
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Synthetic peptide within human GDF15 aa 241-290 / 308.
Species Reactivity
Human
Validated Applications
WB
Molecular Weight
Predicted band size: 34 kDa
Positive Control
HepG2 cell lysate, SK-MEL-28 cell lysate, LNCaP cell lysate.
Conjugation
unconjugated
Clone Number
JE39-90
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
WB
-
1:2,000
Target
Function
Growth/differentiation factor 15 is a protein that in humans is encoded by the GDF15 gene. GDF15 was first identified as Macrophage inhibitory cytokine-1 or MIC-1. It is a protein belonging to the transforming growth factor beta superfamily. Under normal conditions, GDF15 is expressed in low concentrations in most organs and upregulated because of injury of organs such as liver, kidney, heart and lung. The function of GDF15 is not fully clear but it seems to have a role in regulating inflammatory pathways and to be involved in regulating apoptosis, angiogenesis, cell repair and cell growth, which are biological processes observed in cardiovascular and neoplastic disorders.
Background References
1. Wang D et al. GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease. Nat Rev Endocrinol. 2021 Oct
2. Johann K et al. The Role of GDF15 as a Myomitokine. Cells. 2021 Nov
Subcellular Location
Secreted.
UNIPROT
Synonyms
GDF 15 antibody
GDF-15 antibody
Gdf15 antibody
GDF15_HUMAN antibody
Growth differentiation factor 15 antibody
Growth/differentiation factor 15 antibody
Macrophage inhibitory cytokine 1 antibody
MIC 1 antibody
Mic-1 antibody
MIC1 antibody
ExpandImages
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Western blot analysis of GDF15 on different lysates with Rabbit anti-GDF15 antibody (HA722551) at 1/1,000 dilution.
Lane 1: HepG2 cell lysate
Lane 2: SK-MEL-28 cell lysate
Lane 3: LNCaP cell lysate
Lysates/proteins at 20 µg/Lane.
Predicted band size: 34 kDa
Observed band size: 34/12.5 kDa
Exposure time: 25 seconds; ECL: K1802;
4-20% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA722551) at 1/1,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1/50,000 dilution was used for 1 hour at room temperature.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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