Grp75 Mouse Monoclonal Antibody [6-A9]

Function

The HSP 70 family comprises four highly conserved proteins, HSP 70, HSC 70, GRP 75 and GRP 78, which serve a variety of roles. HSC 70, GRP 75 and GRP 78 are constitutively expressed in primate cells. HSP 70 expression is strongly induced in response to heat stress. GRP 75 and GRP 78 are unresponsive to heat stress and are induced by glucose deprivation. GRP 75 expression is restricted to the mitochondrial matrix and aids in the translocation and folding of nascent polypeptide chains of both nuclear and mitochondrial origin. GRP 75 expression is restricted to the mitochondrial matrix and aids in the translocation and folding of nascent polypeptide chains of both nuclear and mitochondrial origin. GRP 75 and GRP 78 are unresponsive to heat stress and are induced by glucose deprivation.

Background References

1. Burger K et al. Nuclear phosphorylated Dicer processes double-stranded RNA in response to DNA damage. J Cell Biol 216:2373-2389 (2017).

2. Siu GK et al. Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIa to induce mitochondrial fragmentation. Sci Rep 6:23464 (2016).

Sequence Similarity

Belongs to the heat shock protein 70 family.

Subcellular Location

Mitochondrion. Nucleus.

UNIPROT

SwissProt: P38646 Human

SwissProt: P38647 Mouse

SwissProt: P48721 Rat

Synonyms