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AMPS Rabbit Polyclonal Antibody (HA500092)

Price: Regular price $315.00

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Catalog# HA500092

Rabbit Polyclonal to AMPS

Tested for

  • WB

  • IHC-P

Reacts with

  • Human

  • Mouse

  • Rat

Specifications

Product Type

Rabbit polyclonal primary

Product Name

AMPS Rabbit Polyclonal Antibody (HA500092)

Immunogen

Synthetic peptide within n-terminal human amps.

Host

Rabbit

Positive Control

Jurkatcell lysate, NIH/3T3 cell lysate, mouse skeletal muscle tissue lysate, rat skeletal muscle tissue lysate, mouse brain tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071191

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

54 kDa

Isotype

IgG

TARGET

UNIPROT #

P30566

PROTEIN NAME

AMPS

SYNONYMS

Adenylosuccinase antibody;Adenylosuccinate lyase antibody;ADSL antibody;AMPS antibody;ASase antibody;ASL antibody;OTTHUMP00000199172 antibody;OTTHUMP00000199173 antibody;PUR8_HUMAN antibody

SUBCELLULAR LOCATION

Cytosol.

FUNCTION

Adenylosuccinate lyase (ASL) is an enzyme that catalyzes two reactions in the de novo purine biosynthetic pathway. In both reactions it uses an E1cb elimination reaction mechanism to cleave fumarate off of the substrate. In the first reaction, ASL converts 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR) to 5-aminoimidazole-4-carboxamide ribotide (AICAR) and fumarate. AICAR proceeds through three more reactions before it becomes adenylosuccinate (also called succinyladenosine monophosphate or SAMP), which ASL then splits into adenosine monophosphate (AMP) and fumarate. ASL is important to cells not only because of its involvement in creating purines needed for cellular replication, but also because it helps regulate metabolic processes by controlling the levels of AMP and fumarate in the cell.

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