PPP3CC Rabbit Polyclonal Antibody
Catalog# HA500101
PPP3CC Rabbit Polyclonal Antibody
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WB
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Human
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Mouse
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unconjugated
Overview
Product Name
PPP3CC Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Recombinant protein within human PPP3CC aa 1-200.
Species Reactivity
Human, Mouse
Validated Applications
WB
Molecular Weight
Predicted band size: 58 kDa
Positive Control
HepG2 cell lysate, Mouse hippocampus tissue lysate.
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
-
WB
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1:500-1:1,000
Target
Function
Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene.
Background References
1. Wang H. et. al. Repression of the expression of PPP3CC by ZEB1 confers activation of NF-kappaB and contributes to invasion and growth in glioma cells. Jpn J Clin Oncol. 2018 Feb
2. Osier ND. et. al. Variation in PPP3CC Genotype Is Associated with Long-Term Recovery after Severe Brain Injury. J Neurotrauma. 2017 Jan
Subcellular Location
Cytosol, presynaptic cytosol, mitochondrion, calcineurin complex, cytoplasm, glutamatergic synapse.
Synonyms
calcineurin A gamma antibody
CALCINEURIN A3 antibody
Calcineurin antibody
Calcineurin testis specific catalytic subunit antibody
Calmodulin dependent calcineurin A subunit gamma isoform antibody
Calmodulin-dependent calcineurin A subunit gamma isoform antibody
CALNA3 antibody
CAM PRP catalytic subunit antibody
CAM-PRP catalytic subunit antibody
CNA3 antibody
ExpandImages
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Western blot analysis of PPP3CC on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (HA500101, 1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:5,000 dilution was used for 1 hour at room temperature.
Positive control:
Lane 1: HepG2 cell lysate
Lane 2: Mouse hippocampus tissue lysate
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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