HOXA9 Rabbit Polyclonal Antibody
Catalog# HA500135
HOXA9 Rabbit Polyclonal Antibody
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WB
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Human
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unconjugated
Overview
Product Name
HOXA9 Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Synthetic peptide within human HOXA9 aa 110-160.
Species Reactivity
Human
Validated Applications
WB
Target Molecular Weight
Predicted band size: 30 kDa
Positive Control
A431 cell lysate, THP-1 cell lysate, PC-3 cell lysate.
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
1 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
-
WB
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1:1,000-1:5,000
Target
Function
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.
Background References
1. Sun Y. et. al. HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis. Cancer Cell. 2018 Oct
2. de Bock CE. et. al. HOXA9 Cooperates with Activated JAK/STAT Signaling to Drive Leukemia Development. Cancer Discov. 2018 May
Subcellular Location
Nucleus.
UNIPROT
Synonyms
ABD-B antibody
Abd-B, drosophila, homolog of antibody
D6a9 antibody
Homeobox 1G antibody
Homeobox A9 antibody
Homeobox protein Hox-1.7 antibody
Homeobox protein Hox-1G antibody
Homeobox protein Hox-A9 antibody
Homeodomain protein HOXA9 antibody
Hox-1.7 antibody
ExpandImages
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Western blot analysis of HOXA9 on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (HA500135, 1/1,000) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:200,000 dilution was used for 1 hour at room temperature.
Positive control:
Lane 1: A431 cell lysate
Lane 2: THP-1 cell lysate
Lane 3: PC-3 cell lysate
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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