Collagen IV Rabbit Polyclonal Antibody (HA500197)
Catalog# HA500197
Rabbit Polyclonal to Collagen IV
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WB
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IF-Cell
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Human
Positive control:
Lane 1: MCF-7 cell lysate
Lane 2: SH-SY5Y cell lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
Collagen IV Rabbit Polyclonal Antibody (HA500197)
Immunogen
Recombinant protein within c-terminal human collagen iv.
Host
Rabbit
Positive Control
MCF-7 cell lysate, SH-SY5Y cell lysate, SH-SY5Y.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500-1:2,000
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IF-Cell
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1:50-1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
161 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
Collagen IV
SYNONYMS
Collagen alpha-1(IV) chain;Arresten;COL4A1;Collagen IV
SUBCELLULAR LOCATION
Basement membrane.
FUNCTION
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.
CITATIONS
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Xu Ying,et al
Comprehensive analysis of the expression, prognostic, and immune infiltration for COL4s in stomach adenocarcinoma
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WB
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Human
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Citation
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