SLC22A2 Rabbit Polyclonal Antibody (HA500306)
Catalog# HA500306
Rabbit Polyclonal to SLC22A2
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WB
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Human
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Mouse
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Rat
Positive control:
Lane 1: HepG2 cell lysate
Lane 2: 293T cell lysate
Lane 3: Rat brain tissue lysate
Lane 4: Mouse kidney tissue lysate
Lane 5: Mouse brain tissue lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
SLC22A2 Rabbit Polyclonal Antibody (HA500306)
Immunogen
Recombinant protein within human slc22a2 aa 44-150 / 555 (extracellular).
Host
Rabbit
Positive Control
HepG2 cell lysate, 293T cell lysate, rat brain tissue lysate, mouse kidney tissue lysate, mouse brain tissue lysate.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB:1:500-1:1,000
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
63/54/27 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
SLC22A2
SYNONYMS
MGC32628 antibody;OCT 2 antibody;OCT2 antibody;Organic cation transporter 2 antibody;Organic cation transporter antibody;RP11-317M22.2 antibody;Solute carrier family 22 (organic cation transporter) member 2 antibody;Solute carrier family 22 member 2 antibody
SUBCELLULAR LOCATION
Membrane.
FUNCTION
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.
CITATIONS
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Gu, Y., Zhang, N., Zhu, S., Lu, S., Jiang, H., & Zhou, H.
Estradiol reduced 5-HT reuptake by downregulating the gene expression of Plasma Membrane Monoamine Transporter (PMAT, Slc29a4) through estrogen receptor β and the MAPK/ERK signaling pathway
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WB
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Rat
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Citation
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