TNFR2 Rabbit Polyclonal Antibody (HA500332)
Catalog# HA500332
Rabbit Polyclonal to TNFR2
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IHC-P
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FC
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Human
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Mouse
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Rat
Specifications
Product Type
Rabbit polyclonal primary
Product Name
TNFR2 Rabbit Polyclonal Antibody (HA500332)
Immunogen
Recombinant protein within human tnfr2 aa 20-461 / 461.
Host
Rabbit
Positive Control
Rat epididymis tissue, human uterus tissue, mouse testis tissue, HepG2.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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IHC-P:1:50-1:100
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FC:1:50-1:100
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 1%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
48 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
TNFR2
SYNONYMS
CD120b antibody;p75 antibody;p75 TNF receptor antibody;p75TNFR antibody;p80 TNF alpha receptor antibody;p80 TNF-alpha receptor antibody;Soluble TNFR1B variant 1 antibody;TBP-2 antibody;TBPII antibody;TNF R II antibody;TNF R2 antibody;TNF R75 antibody;TNF-R2 antibody;TNF-RII antibody;TNFBR antibody;TNFR-II antibody;TNFR1B antibody;TNFR2 antibody;TNFR80 antibody;TNFRII antibody;Tnfrsf1b antibody;TNR1B_HUMAN antibody;Tumor necrosis factor beta receptor antibody;Tumor necrosis factor binding protein 2 antibody;Tumor necrosis factor receptor 2 antibody;Tumor necrosis factor receptor superfamily member 1B antibody;Tumor necrosis factor receptor type II antibody;Tumor necrosis factor-binding protein 2 antibody
SUBCELLULAR LOCATION
Cell membrane, Secreted.
FUNCTION
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
CITATIONS
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Celastrol Inhibited Human Esophageal Cancer by Activating DR5-Dependent Extrinsic and Noxa/Bim-Dependent Intrinsic Apoptosis
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WB
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Human
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Citation
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