RRAGA Rabbit Polyclonal Antibody

Function

Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. The activation of GTP-binding proteins is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). The GATOR1 complex functions as a GAP and stimulates RRAGA GTPase activity to turn it into its inactive GDP-bound form. Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.

Background References

1. Tsun Z.Y., Bar-Peled L., Chantranupong L., Zoncu R., Wang T., Kim C., Spooner E., Sabatini D.M. The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol. Cell 52:495-505(2013).

2. Li Y., Kang J., Horwitz M.S. Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers. J. Virol. 71:1576-1582(1997).

Subcellular Location

Lysosome, Cytoplasm, Nucleus.

UNIPROT

SwissProt: Q7L523 Human

SwissProt: Q80X95 Mouse

Entrez Gene: 117044 Rat

Synonyms

Adenovirus E3 14.7 kDa-interacting protein 1 antibody

FIP-1 antibody

Rag A antibody

RagA antibody

Ras-related GTP-binding protein A antibody

RRAGA antibody

RRAGA_HUMAN antibody