TAB1 Rabbit Polyclonal Antibody (HA500400)

UNIPROT #

Q15750

PROTEIN NAME

TAB1

SYNONYMS

2310012M03Rik antibody;3'-Tab1 antibody;MAP3K7IP 1 antibody;MAP3K7IP1 antibody;MGC57664 antibody;Mitogen activated protein kinase kinase kinase 7 interacting protein 1 antibody;Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 antibody;TAB 1 antibody;TAB1 antibody;TAB1_HUMAN antibody;TAK1 binding protein 1 antibody;TAK1-binding protein 1 antibody;TGF beta activated kinase 1 binding protein 1 antibody;TGF-beta activated kinase 1/MAP3K7 binding protein 1 antibody;TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 antibody;TGF-beta-activated kinase 1-binding protein 1 antibody;Transforming growth factor beta activated kinase binding protein 1 antibody

SUBCELLULAR LOCATION

Cytosol.

FUNCTION

Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the TAB1 gene. The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta, interleukin-1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. TAB1 contains multiple amino acid sites that are phosphorylated and ubiquitinated. This protein plays an important role in skin homeostasis, wound repair, and oncogenesis.