PEMT Rabbit Polyclonal Antibody

Function

The PEMT enzyme converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) via three sequential methylations by S-adenosyl methionine (SAM). The enzyme is found in endoplasmic reticulum and mitochondria-associated membranes. It accounts for ~30% of PC biosynthesis, with the CDP-choline, or Kennedy, pathway making ~70%. PC, typically the most abundant phospholipid in animals and plants, accounts for more than half of cell membrane phospholipids and approximately 30% of all cellular lipid content. The PEMT pathway is therefore crucial for maintaining membrane integrity. PC made via the PEMT pathway can be degraded by phospholipases C/D, resulting in the de novo formation of choline. Thus, the PEMT pathway contributes to maintaining brain and liver function and larger-scale energy metabolism in the body. PC molecules produced by PEMT-catalyzed methylation of PE are more diverse, and tend to contain longer chain, polyunsaturated species and more arachidonate, whereas those produced via the CDP-choline pathway are typically composed of medium-length, saturated chains. A major pathway for hepatic PC utilization is secretion of bile into the intestine. PEMT activity also dictates normal very low-density lipoprotein (VLDL) secretion by the liver. PEMT is also a significant source and regulator of plasma homocysteine, which can be secreted or converted to methionine or cysteine.

Background References

1. Piras IS et al. Hepatic PEMT Expression Decreases with Increasing NAFLD Severity. Int J Mol Sci. 2022 Aug

2. Gadiya Y et al. PEMT: a patent enrichment tool for drug discovery. Bioinformatics. 2023 Jan

Subcellular Location

Endoplasmic reticulum membrane, Mitochondrion membrane.

UNIPROT

SwissProt: Q61907 Mouse

SwissProt: Q08388 Rat

Synonyms

PEAMT antibody

PEMPT antibody

PEMT antibody

PEMT_HUMAN antibody

PEMT2 antibody

phosphatidylethanolamine N methyltransferase antibody

Phosphatidylethanolamine N-methyltransferase antibody

PNMT antibody