POLR2A Rabbit Polyclonal Antibody

Function

DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that is encoded by the POLR2A gene in humans. This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA-binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.

Background References

1. Zhang D et al. USP10 Inhibits Ferroptosis via Deubiquinating POLR2A in Head and Neck Squamous Cell Carcinoma. Adv Sci (Weinh). 2025 Sep

2. Liu C et al. POLR2A blocks osteoclastic bone resorption and protects against osteoporosis by interacting with CREB1. J Cell Physiol. 2021 Jul

Subcellular Location

Nucleus, Cytoplasm, Chromosome.

UNIPROT

SwissProt: P24928 Human

SwissProt: P08775 Mouse

Entrez Gene: 363633 Rat

Synonyms

DNA-directed RNA polymerase II subunit RPB1

RNA polymerase II subunit B1

3'-5' exoribonuclease

DNA-directed RNA polymerase II subunit A

DNA-directed RNA polymerase III largest subunit

RNA-directed RNA polymerase II subunit RPB1

POLR2A

POLR2